反应详情

A solution of 1-(methoxymethyl)-3-(4,5,6,7-tetrahydro-7-hydroxybenzo[b]thien-4-yl)urea (0.35 g., 1.37 mmole) in acetone (40 ml.) is treated with manganese dioxide (3.5 g.). After 2 hours stirring the reaction mixture is filtered through celite, the cake washed thoroughly with acetone and the filtrate and washings evaporated to furnish 0.32 g. on 90.7% yield of the title compound as a crystalline solid, m.p. 155°-158° C. Recrystallization from hot acetone affords the analytical sample, m.p. 159°-162° C.

1. filtrationis filtered through celite
2. washthe cake washed thoroughly with acetone
3. customthe filtrate and washings evaporated
4. customto furnish 0.32 g