反应详情

To 17.11 g. (0.05 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid is added 1 ml. of DMF, followed by 50 ml. of thionyl chloride. After evolution of HCl ceases, the thionyl chloride excess is removed in vacuum. The residue is extracted with methylene chloride and the methylene chloride solution washed with ice water, dried, and the solvent removed, leaving 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride.

1. customAfter evolution of HCl ceases, the thionyl chloride excess is removed in vacuum
2. extractionThe residue is extracted with methylene chloride
3. washthe methylene chloride solution washed with ice water
4. customdried
5. customthe solvent removed