1-(2-Hydroxyethyl)piperazine → HCID 20347475, compound

HRID 1701283Notes

Reaction equation

HRID 1701283 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][C:14]([CH2:17][CH3:18])=[CH:13][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[C:10](O)=O.[OH:19][CH2:20][CH2:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>>[CH2:17]([C:14]1[CH:15]=[CH:16][C:2]2[N:1]=[C:10]([N:25]3[CH2:26][CH2:27][N:22]([CH2:21][CH2:20][OH:19])[CH2:23][CH2:24]3)[C:6]3=[CH:7][CH:8]=[CH:9][N:5]3[CH2:4][C:3]=2[CH:13]=1)[CH3:18]

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 20347486HCID 20347486, compound

Product 1

HCID 20347475HCID 20347475, compound

Procedure

In the manner described in Example 5, reaction of 1-(2-amino-5-ethylbenzyl)-2-pyrrolecarboxylic acid with N-(β-hydroxyethyl)piperazine provides the title compound after cyclization.

Sources & evidence

ORD record
ord-75f1a4de56374f5cbd991d7fea3ac6f3
Source dataset
uspto-grants-1980_03
Patent number
US04192803

Reaction notes

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