Nitric Acid → N-(5-nitro-indan-2-yl)-acetamide

Participants

Reaction Conditions

Reaction Steps

18.5 g. of the acetamide (0.105 mole) was added in portions to nitric acid (185 ml.; d=1.51), stirred and maintained below 0° C. The reaction was allowed to warm to 0° C., poured onto crushed ice and extracted with chloroform which was washed with 5% aqueous sodium bicarbonate and evaporated to give crude N-acetyl-5-nitro-2-indanamine which was purified by crystallization from isopropanol, m.p. 143°-144° C.

Provenance & Evidence