反应详情

温度

80 °C

A mixture of 28 g of 3-p-chlorobenzoyl-2-methyl-benzonitrile, 210 cc of glacial acetic acid, 210 cc of water and 210 cc of concentrated sulfuric acid was refluxed overnight and after cooling to 80° C., the reaction mixture was added to a water-ice mixture. The mixture was vacuum filtered and the resulting precipitate was washed with water until the wash waters were neutral and then dried under reduced pressure to obtain 29.9 g of 3-p-chlorobenzoyl-2-methyl-benzoic acid melting at 205° C. The product was soluble in ethanol and chloroform and slightly soluble in ethyl ether. After crystallization from methanol for analysis, the product melted at 206° C.

1. temperaturewas refluxed overnight
2. filtrationfiltered
3. washthe resulting precipitate was washed with water until the wash waters
4. customdried under reduced pressure