2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → Ethyl 2-cyano-3-(5-phenyl-2-pyridylamino)acrylate

Participants

Reaction Steps

A mixture of 2-amino-5-phenylpyridine (1.19 g., 6.99 mmoles) and ethyl ethoxymethylenecyanoacetate (1.18 g., 6.99 mmoles) was fused at an oil bath temperature of 100° for 15 minutes. The product was recrystallized from toluene to give the title compound (1.3 g.), m.p. 126°-134°. An additional crop of product (0.3 g.), m.p. 119°-126° was obtained from the mother liquors. Total yield of product, 1.6 g. (78%).

Provenance & Evidence