反应详情

A solution of 2-amino-3-methylpyridine (5.0 g., 0.0462 mole) and ethyl ethoxymethylenecyanoacetate (7.82 g., 0.0462 mole) in toluene (4 ml.) was heated for 15 minutes by means of an oil bath maintained at 100°. The solution was cooled and the title compound (9.1 g., 85%) collected by filtration. The product, m.p. 139°-143°, was recrystallized from 2-propanol to give an analytical sample, m.p. 144°-146°.

1. temperaturemaintained at 100°
2. temperatureThe solution was cooled
3. filtrationthe title compound (9.1 g., 85%) collected by filtration
4. customThe product, m.p. 139°-143°, was recrystallized from 2-propanol
5. customto give an analytical sample, m.p. 144°-146°