HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 70586608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 86736865 | HCID 86736865 | — |
| Product | HCID 70586608 | HCID 70586608 | — |
Reaction Steps
A solution of 11β-diethylaminoacetoxy-2α,3α-epoxy-5α-pregnan-20-one (800 mg) in concentrated hydrochloric acid (6 ml) was kept at room temperature for 15 minutes and then diluted with a large excess of sodium bicarbonate solution. The precipitated solid (767 mg) was collected by filtration and purified by preparative TLC (ethylacetate) and crystallization from petroleum ether to afford title compound, (305 mg). m.p. 182°-187°, [α]D +101.4°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04192871 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-ae6abe34969c4e7792e8039023327b8c |
| Source note | uspto-grants-1980_03 |