Hydrogen Bromide → HCID 70586537, compound

Participants

Reaction Steps

A mixture of 11β-(N-butyl-N-methylaminoacetoxy)-2α,3α-epoxy-5α-pregnan-20-one (1.6 g) and aqueous 47% hydrobromic acid (2 ml) in chloroform (100 ml) was stirred at room temperature for 1 hour. The solution was washed with dilute sodium bicarbonate solution and water, dried and evaporated in vacuo to give a foam. Crystallization from ethyl acetate-petroleum ether afforded title compound, m.p. 108°-110°, [α]D +95° (1.303 g).

Provenance & Evidence