Sodium borohydride → 20,20-Ethylenedioxy-5alpha-pregn-2-en-11beta-ol

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Reaction Steps

20,20-Ethylenedioxy-5α-pregn-2-en-11-one (9.3 g) in hot ethanol (300 ml) was treated with sodium borohydride (5.5 g) in water (30 ml), and the mixture was refluxed on a steam bath for 1 1/2 hours, concentrated by evaporation to about 200 ml, the excess borohydride destroyed by the addition of glacial acetic acid (0.5 ml), and the mixture poured on to ice-water to give a white crystalline precipitate. The precipitate was filtered off, washed with water and dried in vacuo to give title compound (9.05 g), as colourless needles, m.p. 141°-145°, [α]D +64°.

Provenance & Evidence