Sodium borohydride → HCID 70583636, compound

Participants

Reaction Steps

20,20-Ethylenedioxy-3α-hydroxy-6β-methyl-5α-pregnan-11-one (1.36 g) was dissolved in propan-2-ol (90 ml) and a solution of sodium borohydride (500 mg) in water (10 ml) was added. The solution was stirred at 20° overnight and then diluted with water (200 ml). Extraction with chloroform (2×100 ml) gave, on evaporation of the extract, a colourless gum which was dissolved in a mixture of acetone (50 ml) and 2N-hydrochloric acid (5 ml). After 2 hours the solution was diluted with water (100 ml) and extracted with chloroform (2×50 ml). Evaporation of the extract gave a colourless gum which was crystallised from methanol (25 ml) to give the title compound (700 mg), m.p. 211°-213°.

Provenance & Evidence