m-Chloroperbenzoic acid → HCID 86736871, compound

Participants

Reaction Steps

11β-Chloroacetoxy-5α-pregn-2-en-20-one (1.25 g) in chloroform (50 ml) was treated with m-chloroperbenzoic acid (85%; 700 mg) and the solution was stirred at room temperature for 4 hours. Chloroform (50 ml) was added, and the solution was washed with potassium bicarbonate solution and with water; it was then dried over sodium sulphate and evaporated to a white foam which was triturated with ether to give title compound (1.05 g) as colourless prisms, m.p. 163°-169°, [α]D +107°.

Provenance & Evidence