HCID 70584169, compound → HCID 70585544, compound

Participants

Reaction Steps

11β-N,N-Dipropylaminoacetoxy-3β-hydroxy-5α-pregn-16-en-20-one (150 mg) was stirred with 5% palladium on charcoal (100 mg) in ethyl acetate (25 ml) at 20° under hydrogen. After 1 hour the catalyst was separated off using a Kieselguhr filter aid and the ethyl acetate was evaporated to leave a white solid. This was recrystallised from ethyl acetate in petroleum ether to give title compound as white crystals, m.p. 145 to 147.5 [α]D +85.2°. (89 mg).

Provenance & Evidence