Water → HCID 86736881, compound

Participants

Reaction Steps

3β,11β-Bischloroacetoxy-5α-pregn-16-en-20-one (1.2 g) was stirred at 100° in dioxan (20 ml) containing water (4 ml) with sodium bicarbonate (1.26 g) for 4 hours. The mixture was cooled, poured into water and the precipitate collected by filtration, dried and filtered through silica gel (20 g) in ethylacetate. The eluate was evaporated and the residue crystallised from petrol containing a little ethyl acetate to yield the title compound (684 mg), m.p. 160.5°-162°, [α]D +75.2°.

Provenance & Evidence