HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 20341563, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Propenamide, N-(3-aminopropyl)-2-methyl-, hydrochloride (1:1) | HCID 10375005 | — |
| Reactant | 3-Chloropropanoyl isocyanate | HCID 13572374 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 20341563 | HCID 20341563 | 70% |
Reaction Steps
Pyridine (7.9 g, 0.1 mole) was added dropwise to a mixture of β-chloropropionylisocyanate (13.3 g, 0.1 mole) and N-(3-aminopropyl)methacrylamide hydrochloride (17.8 g, 0.1 mole) in N,N-dimethylformamide (80 ml) at 0° C. The mixture was left to stir overnight at ambient temperature. This mixture was then poured onto ice, and the product filtered. Recrystallization from absolute ethanol (400 ml) gave 1-(3-chloropropionyl)-3-methacrylamidopropyl urea, mp 131°-2° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04193795 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-634c1f53249d4e48851edfde76aaa31b |
| Source note | uspto-grants-1980_03 |