N,N-Dimethyl-4-nitrobenzylamine → Benzenemethanamine, 4-amino-N,N-dimethyl-

Participants

Reaction Steps

In a 30 l autoclave was placed a suspension in which 10 g. of a palladium-carbon catalyst was suspended in 50 ml of ethanol, and 890 g. of N,N-dimethyl-p-nitrobenzylamine and 10 l of ethanol were charged thereinto. Then, hydrogenation was carried out at 35° C. under 30 atm., and when the consumption of hydrogen was ceased, the reaction mixture was taken out of the autoclave. After the palladium-carbon was removed by filtration and the ethanol was removed by distillation to concentrate the filtrate, the resulting residue was distilled under reduced pressure to give a light-yellow liquid which was the desired product boiling at 105° to 108° C./2 mmHg. Yield: 675 g. (90%)

Provenance & Evidence