Acetic Acid → HCID 56631149, compound

Participants

Reaction Steps

A solution of 0.69 g. of (20S)-1α,3β-dihydroxy-20-methyl-21-tetrahydropyranyloxypregna-5-ene in 6.9 ml. of acetic acid and 2.1 ml. of water was warmed to 80° and an additional 3.2 ml. of water was added. The mixture was kept at 80° for one hour, cooled and poured into water. The suspension was extracted with ethyl acetate and the organic solution was washed with saturated sodium bicarbonate solution and water. After drying and evaporation under vacuum, 0.6 g. of (20S)-20-methyl-1α,3β,21-trihydroxypregna-5-ene was obtained. Recrystallization from acetone gave 0.3 g. of colorless prisms, m.p. 208°-209°; [α]D =-29° (c=0.5, methanol).

Provenance & Evidence