HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → Diethyl 2-acetyl-3-methylbutanedioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | Ethyl 2-chloropropionate | HCID 10807 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 14567419 | HCID 14567419 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Diethyl 2-acetyl-3-methylbutanedioate | HCID 12354293 | — |
Reaction Steps
Process according to claim 4 wherein ethyl chloropropionate is reacted with ethyl acetoacetate in a toluene mixture containing tricaprylyl methylammonium chloride as phase transfer agent, potassium iodide as iodide ion source, potassium carbonate, milled to below about 80 mesh as deprotonating base at 75° to 80° C. for a time sufficient to form diethyl α-acetyl-α'-methylsuccinate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04194053 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-1e0d5db8f1814678b050de04cc5a8bef |
| Source note | uspto-grants-1980_03 |