HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphoric Acid → 5-Methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | N-Methyl-2-piperidone | HCID 13603 | — |
| Reactant | 5-Methoxyindole | HCID 13872 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 3055249 | — |
Reaction Steps
Using the procedure of J. Org. Chem., Vol. 40, No. 17 (1975), p. 2525, 1-methyl-piperidone and 5-methoxy-1H-indole were condensed in refluxing acetic acid in the presence of phosphoric acid to obtain 5-methoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole melting at 235° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195081 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-047f7d9499d240148ea7563179a1ddd2 |
| Source note | uspto-grants-1980_03 |