HuagongsheHuagongshe Chemistry Print Report · For research reference only
Indole → 3-(1-Methyl-1,2,3,6-tetrahydropyrid-4-yl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Indole | HCID 798 | — |
| Reactant | Phosphoric Acid | HCID 1004 | — |
| Reactant | N-Methyl-2-piperidone | HCID 13603 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(1-Methyl-1,2,3,6-tetrahydropyrid-4-yl)indole | HCID 152215 | — |
Reaction Steps
Using the same procedure of Example 1, 1-methyl-piperidone and 1H-indole were condensed in refluxing acetic acid in the presence of phosphoric acid to obtain 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole melting at 228°~229° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195081 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-e27d458fa0bf4fea9c100af97bf234f1 |
| Source note | uspto-grants-1980_03 |