Hydrochloric Acid → HCID 54128756, compound

Participants

Reaction Steps

To a solution maintained at 0° C. of 12.5 g of the ester obtained according to (a) and 8.79 g thiophene-2-carboxylic acid chloride in 130 ml methylene chloride, there are added little by little 7.9 g aluminium chloride. The mixture is then maintained at reflux temperature for 6 hours and then poured into a mixture of ice and hydrochloric acid. The final product is recrystallised from methanol. There are obtained, with an 85% yield, 16.35 g of the ester which melts at 85° C.

Provenance & Evidence