Potassium Hydroxide → Acetic acid, ((5,6,7,8-tetrahydro-4-(2-thienylcarbonyl)-1-naphthalenyl)oxy)-

HRID 1701718Notes

Reaction equation

HRID 1701718 reaction equation
[C:1]1([C:6]([C:8]2[C:17]3[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=3[C:11]([O:18][CH2:19][C:20]([O:22]C)=[O:21])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>C(O)C.O>[C:1]1([C:6]([C:8]2[C:17]3[CH2:16][CH2:15][CH2:14][CH2:13][C:12]=3[C:11]([O:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:10][CH:9]=2)=[O:7])[S:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 54128756HCID 54128756, compound

Product 1

HCID 3052165Acetic acid, ((5,6,7,8-tetrahydro-4-(2-thienylcarbonyl)-1-naphthalenyl)oxy)-

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

9 g of the ester according to (b) are dissolved in 100 ml aqueous ethanol. 1.8 g potassium hydroxide dissolved in 25 ml water are added and the mixture refluxed for 8 hours. The ethanol is evaporated and the remaining aqueous phase acidified by addition of mineral acid. The acid is extracted in ethyl ether.

Workup

  1. additionare added
  2. temperaturethe mixture refluxed for 8 hours
  3. customThe ethanol is evaporated
  4. additionthe remaining aqueous phase acidified by addition of mineral acid
  5. extractionThe acid is extracted in ethyl ether

Sources & evidence

ORD record
ord-0d63b95a8d504f42b3cff22bb8adeb69
Source dataset
uspto-grants-1980_03
Patent number
US04195093

Reaction notes

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