HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2,3-Dichloro-5-(chloromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (5,6-Dichloropyridin-3-yl)methanol | HCID 21882961 | — |
| Product | 2,3-Dichloro-5-(chloromethyl)pyridine | HCID 10176536 | — |
Reaction Steps
2,3-Dichloro-5-hydroxymethyl-pyridine is reacted in a known manner with thionyl chloride to give 5-chloromethyl-2,3-dichloro-pyridine and the latter is reacted with sodium cyanide, without additional purification (for example analogously to L. A. Carlson et al., Acta Pharm. Suecica 9, 411 (1972)). 5,6-Dichloro-pyridine-3-acetonitrile, thus obtained, melts at 72°-75° C. after recrystallisation from ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195090 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-094b3d4c72d5409c841d749bec1227c2 |
| Source note | uspto-grants-1980_03 |