HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Methyl-3-{[2-phenyl-3-(4-phenyl-3-butyl)-oxazolidin-5-yl]-methoxy}-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Bromo-3-methylpyridine | HCID 220832 | — |
| Reactant | [2-Phenyl-3-(4-phenylbutan-2-yl)-1,3-oxazolidin-5-yl]methanol | HCID 53876813 | — |
| Product | 3-Methyl-3-{[2-phenyl-3-(4-phenyl-3-butyl)-oxazolidin-5-yl]-methoxy}-pyridine | HCID 70524736 | — |
Reaction Steps
31.1 g of 2-phenyl-3-(1-phenyl-3-butyl)-5-hydroxymethyl-oxazolidine, dissolved in 150 ml of dimethylformamide, are reacted with 6.5 g of sodium hydride dispersion (55% strength) and subsequently with 34.4 g of 2-bromo-3-methyl-pyridine over the course of 18 hours. Crude 3-methyl-3-{[2-phenyl-3-(4-phenyl-3-butyl)-oxazolidin-5-yl]-methoxy}-pyridine is thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195090 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-8b4219c5ad6f43758f88b513c84ac8e0 |
| Source note | uspto-grants-1980_03 |