HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 20483402, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Phenyl-3-isopropyl-5-hydroxymethyloxazolidine | HCID 12566198 | — |
| Reactant | 2,3-Dichloro-5-methylpyrazine | HCID 12858134 | — |
| Product | HCID 20483402 | HCID 20483402 | — |
Reaction Steps
Analogously to the description in Example 11, 8.2 g (0.05 mol) of 2,3-dichloro-5-methyl-pyrazine, 11 g (0.05 mol) of 2-phenyl-3-isopropyl-5-hydroxymethyl-oxazolidine and 3.4 g of a 50% strength suspension of sodium hydride in paraffin oil give 2-chloro-3-(3'-isopropylamino-2'-hydroxy-propoxy)-5-methyl-pyrazine, melting point 109°-110° C. when crystallised from benzene. The fumarate prepared therefrom by means of fumaric acid crystallises from methanol-ether, melting point 164°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195090 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-66de59086ff74f0396f40500e86e3dea |
| Source note | uspto-grants-1980_03 |