反应详情

Ethyl 5-(chloromethyl)-2-furoate (0.1 mole) is refluxed with diethylamine (0.25 mole) in 40 ml of benzene for one hour. The benzene solution is filtered off and washed with water. The organic layer is separated and dried over magnesium sulfate. The magnesium sulfate is removed by filtration and the organics are evaporated to dryness. The residue is distilled to give a pure fraction of ethyl 5-(N,N-diethylaminomethyl)-2-furoate boiling at 97°-106° C. at 0.1 mm of Hg.

1. filtrationThe benzene solution is filtered off
2. washwashed with water
3. customThe organic layer is separated
4. dry with materialdried over magnesium sulfate
5. customThe magnesium sulfate is removed by filtration
6. customthe organics are evaporated to dryness
7. distillationThe residue is distilled