HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → Methyl 3-Hydroxybenzo[d]isothiazole-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | 3-Oxo-1,2-benzisothiazoline-6-carboxylic acid | HCID 19076703 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Methyl 3-Hydroxybenzo[d]isothiazole-6-carboxylate | HCID 19076707 | — |
Reaction Steps
A solution of 19.5 g (0.1 mole) of 3-oxo-1,2-benzisothiazoline-6-carboxylic acid in 40 ml of isopropanol is treated with an excess of a solution of diazomethane in ether added at 0° C. with stirring over a period of 10 minutes. The reaction mixture is evaporated to dryness and the 3-oxo-1,2-benzisothiazoline-6-carboxylic acid methyl ester is obtained as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195023 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-420242b057044a1b96a6e31d8a4cf5fa |
| Source note | uspto-grants-1980_03 |