HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Furancarbonyl chloride → 2-(2-Furoyl)-3-oxo-1,2-benzisothiazoline-6-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Furancarbonyl chloride | HCID 68242 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Methyl 3-Hydroxybenzo[d]isothiazole-6-carboxylate | HCID 19076707 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-Furoyl)-3-oxo-1,2-benzisothiazoline-6-carboxylic acid methyl ester | HCID 54361628 | — |
Reaction Steps
A mixture of 2-furoyl chloride (0.1 mole) and 3-oxo-1,2-benzisothiazoline-6-carboxylic acid methyl ester, 1,1-dioxide, sodium salt, from example 3C, above, is refluxed in 100 ml of tetrahydrofuran for 3 hours. The reaction mixture is filtered hot and the filtrate is concentrated to give the product. The product is triturated with ether and air dried to give 2-(2-furoyl)-3-oxo-1,2-benzisothiazoline-6-carboxylic acid methyl ester, 1,1-dioxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04195023 |
| Source dataset | uspto-grants-1980_03 |
| ORD ID | ord-819bb72c2d9d4f309cbff44ce71cedba |
| Source note | uspto-grants-1980_03 |