HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1701809Generated: October 30, 2026
3-Nitrophenol → 3-[2-(Cyclohexyloxy)ethoxy]nitrobenzene
https://huagongshe.com/reaction/1701809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Nitrophenol | HCID 11137 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | 2-(Cyclohexyloxy)ethyl 4-methylbenzene-1-sulfonate | HCID 11380992 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-[2-(Cyclohexyloxy)ethoxy]nitrobenzene | HCID 15583078 | 95.6% |
Reaction Steps
To a solution of 6.8 g of sodium ethoxide and 15 g of m-nitrophenol in 250 ml of dimethylformamide, 28 g of cyclohexyloxyethyl p-toluenesulfonate were added. After heating at 100° C. for 2 hours, the resulting mixture was diluted with water and extracted with benzene. The solvent was removed under reduced pressure, and the residue was purified by vacuum distillation to give 23.8 g of 3-[2-(cyclohexyloxy)ethoxy]nitrobenzene. B.P., 118°-124° C./0.1 mmHg. nD27 1.5380.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04378992 |
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| Source dataset | uspto-grants-1983_04 |
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| ORD ID | ord-4b49e88f7b8e443fb09dab50b3d7cb1f |
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| Source note | uspto-grants-1983_04 |
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