反应详情

To a solution of 5.2 ml of isopropylamine in 50 ml of diethyl ether cooled in an ice bath, a solution of 4.4 g of 2-cyano-3-fluorobenzenesulphonylchloride in 50 ml of diethylether was added dropwise while stirring; reaction temperature approx. 5° C. After leaving to stand at room temperature for one hour, the reaction mixture was washed twice with ice water, dried on anhydrous Na2SO4, filtered and evaporated to dryness. The desired product was obtained in a yield of 4.16 g; melting-point 97°-105° C.

1. customreaction temperature approx. 5° C
2. customAfter leaving
3. washthe reaction mixture was washed twice with ice water
4. dry with materialdried on anhydrous Na2SO4
5. filtrationfiltered
6. customevaporated to dryness