HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-(2-Amino-1-hydroxyethyl)-2-hydroxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 5-((Bis(benzyl)amino)acetyl)salicylamide | HCID 121727 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(2-Amino-1-hydroxyethyl)-2-hydroxybenzamide | HCID 15565663 | — |
Reaction Steps
To 5-[2-(dibenzylamino)acetyl]salicylamide (75.0 g, 0.200 mmol) and acetic acid (24.0 g, 0.40 mmol) in 1.0 liter methanol, add 5% palladium/carbon (40.0 g). Hydrogenate at 3 atmospheres for 16 hours. Filter the catalyst, concentrate slightly and adjust the volume to give a solution of the title compound of the desired molarity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04379166 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-33d75df1d5c5406ba7463d52e13ff989 |
| Source note | uspto-grants-1983_04 |