Sodium Azide → HCID 135965019, compound

Participants

Reaction Steps

To a solution of the product of Step A (150.5 g, 0.576 mole) in tetrahydrofuran (1 liter) cooled to 20° C., add dropwise sodium azide (37.4 g, 0.576 mole) in water (450 ml) and stir for five hours. Partially evaporate the solvent and extract the concentrated reaction mixture with chloroform. Dry the organic phase and evaporate in vacuo to obtain 2-azido-4'-hydroxy-3'-methylthioacetophenone, mp. 124°-129° C.

Provenance & Evidence