4-(Chloromethyl)pyridinium chloride → HCID 13043949, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 4-chloromethylpyridine hydrochloride (82 g) in gently boiling ethanol (260 cc) is added dropwise and in the course of 30 minutes to a suspension of thiourea (45.5 g) in boiling ethanol (260 cc). The reaction mixture is stirred for 1 hour 30 minutes at the boil and then cooled to 5° C. The resulting crystals are filtered off, washed twice with ethanol (60 cc in total) and dried under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 20° C. 2-(Pyrid-4-yl-methyl)-isothiourea dihydrochloride (116 g), melting at 260° C., is thus obtained.

Provenance & Evidence