Pyrazine, 2-(chloromethyl)- → HCID 20505187, compound

Participants

Reaction Conditions

Reaction Steps

A solution of chloromethylpyrazine (88 g) in ethanol (200 cc) is added dropwise and in the course of 15 minutes to a suspension of thiourea (68 g) in boiling ethanol (370 cc). After stirring for 1 hour 30 minutes at the boil, the reaction mixture is cooled for 15 hours at a temperature of about 5° C. The resulting crystals are filtered off, washed twice with ethanol (120 cc) and dried under reduced pressure (20 mm Hg; 2.7 kPa) at a temperature of about 20° C. 2-(Pyrazinylmethyl)-isothiourea hydrochloride (74 g), melting at 183° C., is thus obtained.

Provenance & Evidence