Water → HCID 13120748, compound

Participants

Reaction Steps

A solution of 0.4 g (0.01 mol) of lithium aluminum hydride in 80 ml of ether was cooled to -30°. A solution of 0.8 g (2.1 mmol) of 8-chloro-6-phenyl-2H,4H-pyrazolo[3,4-d][2]benzazepine-2-acetic acid ethyl ester in 5 ml of tetrahydrofuran was added and the mixture was stirred at -10° to -5° for 15 min. The reaction mixture was hydrolized by addition of 2 ml of water, diluted with methylene chloride and filtrated over Celite. The filtrate was evaporated and the residue was crystallized from ether to yield colorless crystals which were recrystallized for analysis from ethyl acetate, hexane, mp 173°-175°.

Provenance & Evidence