2-Amino-5-methylbenzoic acid → HCID 15580771, compound

HRID 1701948Notes

Reaction equation

HRID 1701948 reaction equation
[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[C:12]([O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=O)=[CH:18][CH:17]=1)(=[O:14])[CH3:13]>N1C=CC=CC=1>[C:12]([O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]2[O:8][C:7](=[O:9])[C:6]3[CH:10]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]=3[N:11]=2)=[CH:18][CH:17]=1)(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 762552-Amino-5-methylbenzoic acidHCID 2756254p-Acetoxybenzoyl chloride

Product 1

HCID 15580771HCID 15580771, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

10 gm (0.066 mol) of 5-methyl-anthranilic acid were dissolved in 65 ml of pyridine, and the solution was mixed, while cooling and stirring, with 15.7 gm (0.066 mol+20%) of 4-acetoxy-benzoyl chloride. After 2 hours the reaction was finished, and the reaction mixture was poured into ice water. The crystalline precipitate thus formed was suction-filtered off, washed well with water and dried.

Workup

  1. additionthe solution was mixed
  2. temperaturewhile cooling
  3. customThe crystalline precipitate thus formed
  4. filtrationwas suction-filtered off
  5. washwashed well with water
  6. customdried

Sources & evidence

ORD record
ord-ea0b2dea4f914a77bfffc0d52b205ca3
Source dataset
uspto-grants-1983_04
Patent number
US04379788

Reaction notes

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