HCID 15580774, compound → 83722-02-5

HRID 1701949Notes

Reaction equation

HRID 1701949 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:20]([CH3:21])[C:19](=[O:22])[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:23][CH3:24])[CH:17]=3)[N:12]=2)=[CH:7][CH:6]=1)(=O)C>N>[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[N:20]([CH3:21])[C:19](=[O:22])[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([O:23][CH3:24])[CH:17]=3)[N:12]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 1

HCID 15580774HCID 15580774, compound

Product 1

HCID 13567258183722-02-5

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Conditions

Temperature
0 °C

Procedure

80.3 gm (0.247 mol) of 2-(4-acetoxy-phenyl)-3-methyl-6-methoxy-3,4-dihydro-quinazolin-4-one were suspended in 800 ml of concentrated aqueous ammonia, and the suspension was heated for 1.5 hours on a steam bath, whereby at first a clear solution was obtained, and after about 60 minutes the formation of a white precipitate began. After cooling to 0° C., the product was suction-filtered off, washed with water and dried at 80° C. in a circulating air drier.

Workup

  1. temperaturethe suspension was heated for 1.5 hours on a steam bath
  2. customwhereby at first a clear solution was obtained
  3. filtrationthe product was suction-filtered off
  4. washwashed with water
  5. customdried at 80° C. in a circulating air drier

Sources & evidence

ORD record
ord-adcdc7c9c92f4ceeb87d2746281c2da6
Source dataset
uspto-grants-1983_04
Patent number
US04379788

Reaction notes

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