Epibromohydrin → HCID 13688278, compound

HRID 1701952Notes

Reaction equation

HRID 1701952 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]([CH3:18])[C:16](=[O:19])[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:20][CH3:21])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[CH2:22]([CH:24]1[O:26][CH2:25]1)Br>CS(C)=O>[O:26]1[CH:24]([CH3:22])[CH:25]1[O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]([CH3:18])[C:16](=[O:19])[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([O:20][CH3:21])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 18430EpibromohydrinHCID 13567258183722-02-5

Product 1

HCID 13688278HCID 13688278, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2.8 gm (10 mmols) of 2-(4-hydroxyphenyl)-3-methyl-6-methoxy-3,4-dihydro-quinazolin-4-one were dissolved in 20 ml of dimethylsulfoxide, and the solution was mixed, while stirring, with 1.35 gm (10 mmols+20%) of potassium tert. butylate. Subsequently, 2.8 ml of epibromohydrin were added, and the reaction mixture was stirred at room temperature until the reaction had gone to completion. After pouring the reaction mixture into ice water, the crystalline precipitate formed thereby was suction-filtered off, washed well with water and dried.

Workup

  1. additionthe solution was mixed
  2. customthe crystalline precipitate formed
  3. filtrationthereby was suction-filtered off
  4. washwashed well with water
  5. customdried

Sources & evidence

ORD record
ord-158a26fcfe3645848e33e67fc40cdd24
Source dataset
uspto-grants-1983_04
Patent number
US04379788

Reaction notes

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