Epibromohydrin → HCID 13072446, compound

HRID 1701961Notes

Reaction equation

HRID 1701961 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]([CH3:14])[C:12](=[O:15])[C:11]3[N:16]=[CH:17][CH:18]=[CH:19][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.[CH2:20]([CH:22]1[O:24][CH2:23]1)Br>CS(C)=O>[O:24]1[CH:22]([CH3:20])[CH:23]1[O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]([CH3:14])[C:12](=[O:15])[C:11]3[N:16]=[CH:17][CH:18]=[CH:19][C:10]=3[N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 18430EpibromohydrinHCID 135672579HCID 135672579, compound

Product 1

HCID 13072446HCID 13072446, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

9.4 gm (0.037 mol) of 2-(4-hydroxy-phenyl)-3-methyl-3,4-dihydro-pyrido[2,3-e]-pyrimidin-4-one were dissolved in 100 ml of dimethylsulfoxide, and the solution was mixed, while stirring with 4.5 gm (0.04 mol) of potassium tert. butylate. After a clear solution was formed, 9.4 ml of epibromohydrin were added, and the reaction mixture was stirred for one hour at room temperature. Thereafter, it was poured into 600 ml of ice water, and the resulting crystalline product was suction-filtered off and dried at 40° C. in a vacuum shelf-drier.

Workup

  1. additionthe solution was mixed
  2. customAfter a clear solution was formed
  3. filtrationthe resulting crystalline product was suction-filtered off
  4. customdried at 40° C. in a vacuum shelf-drier

Sources & evidence

ORD record
ord-66817e97e86c412ca429587badd72df6
Source dataset
uspto-grants-1983_04
Patent number
US04379788

Reaction notes

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