Ammonia → Cyclohexyl isocyanate

Participants

Reaction Steps

3-butyl-4-methyl-2-oxo-piperidine (m.p. 95°-98° C., prepared according to German Offenlegungsschrift No. 1,023,464) is converted according to Example 2 with phenylethyl-isocyanate to 3-butyl-4-methyl-2-oxo-piperidine-1-(N-2-phenylethyl)-carboxamide, this crude product is converted with chlorosulfonic acid to the sulfochloride, the sulfochloride is converted with ammonia to 4-(2-[3-butyl-4-methyl-2-oxo-piperidine-1-carboxamido)-ethyl]-benzenesulfonamide, m.p. 165°-167° C., from which there is obtained with cyclohexyl isocyanate with N-(4-[2-(3-butyl-4-methyl-2-oxo-piperidine-1-carboxamido)-ethyl]-benzenesulfonyl)-N'-cyclohexyl urea, m.p. 123°-125° C. (from methanol).

Provenance & Evidence