HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → 4-[3-(4-Methylpiperazin-1-yl)propyl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | HCID 22174296 | HCID 22174296 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | 4-[3-(4-Methylpiperazin-1-yl)propyl]morpholine | HCID 17958774 | — |
Reaction Steps
143 g (1 mol) of morpholinopropionaldehyde in 143 g of dioxane are forced into 100 g (1 mol) of N-methylpiperazine and 30 g of Raney nickel at 115° C. and a hydrogen pressure of 140 bar, and hydrogenated for 2 hours. The reaction mixture is suction filtered, concentrated by evaporation and distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04379861 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-553cea2c76ae45b29fe2ba0bedc9dbe3 |
| Source note | uspto-grants-1983_04 |