1-(4-Chlorophenyl)-4,4-dimethyl-1,2-bis(1,2,4-triazol-1-yl)-pentan-3-one → 1-(4-Chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-one

HRID 1701998Notes

Reaction equation

HRID 1701998 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8](N2C=NC=N2)[CH:9]([N:16]2[CH:20]=[N:19][CH:18]=[N:17]2)[C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:4][CH:3]=1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[C:9]([N:16]2[CH:20]=[N:19][CH:18]=[N:17]2)[C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 130348531-(4-Chlorophenyl)-4,4-dimethyl-1,2-bis(1,2,4-triazol-1-yl)-pentan-3-one

Product 1

HCID 540228171-(4-Chlorophenyl)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-(4-Chlorophenyl)-4,4-dimethyl-1,2-bis(1,2,4-triazol-1-yl)-pentan-3-one (0.5 g) was heated at 180° C. for 1 hour and at 200° C. for 3 hours on an oil bath. After cooling, the mixture was dissolved in chloroform (50 ml), washed with water (50 ml) and concentrated to give yellow oily substance (0.37 g). Triazole (0.095 g; 99%) was recovered from the aqueous layer by concentration. The oily substance was analyzed by the gas-chromatography under the following conditions:

Workup

  1. temperatureAfter cooling
  2. washwashed with water (50 ml)
  3. concentrationconcentrated
  4. customto give yellow oily substance (0.37 g)
  5. customTriazole (0.095 g; 99%) was recovered from the aqueous layer by concentration

Sources & evidence

ORD record
ord-f8fe5d1cfd2849abaa643b4722d16b20
Source dataset
uspto-grants-1983_04
Patent number
US04379921

Reaction notes

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