Sodium → HCID 53995472, compound

Participants

Reaction Steps

Sodium ethylate was prepared by dissolving 2.3 g of metallic sodium in 100 ml of 99% ethanol, which was then mixed with 6.9 g of triazole and stirred for 30 minutes. The mixture was evaporated to dryness under reduced pressure to give sodium salt of triazole. Thus prepared sodium salt of triazole (0.91 g) was added to a solution of 2-bromo-1-(2,4-dichlorophenyl)-4,4-dimethyl-1-phenylsulfonylpentan-3-one (4.78 g) in acetonitrile (50 ml), and refluxed for 1 hour. After cooling, the mixture was added to 200 ml of ice water and extracted with ethyl acetate. The organic layer was then treated in the same manner as that of the method A to give 3.77 g of 1-(2,4-dichlorophenyl)-4,4-dimethyl-1-phenylsulfonyl-1-penten-3-one.

Provenance & Evidence