HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1702069Generated: October 30, 2026
Diisopropyl Ether → 7-[2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid
https://huagongshe.com/reaction/1702069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 7-(2-Methoxyimino-3-oxo-bromobutyramido)-3-cephem-4-carboxylic acid | HCID 131712504 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-[2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid | HCID 131712444 | 118.7% |
Reaction Steps
7-(2-Methoxyimino-3-oxo-4-bromobutyramido)-3-cephem-4-carboxylic acid (syn isomer, 10 g.) was added to a solution of thiourea (2.81 g.) and sodium acetate (2.22 g.) in methanol (50 ml) and stirred at 30° C. for 5 hours. To the resultant solution was added diisopropyl ether (200 ml.) and stirred at 30 minutes. The precipitates were collected by filtration, washed with diisopropyl ether and dried to give 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid (syn isomer, 11.2 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04379922 |
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| Source dataset | uspto-grants-1983_04 |
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| ORD ID | ord-49bfe9c9e18942f78a78926493c2feea |
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| Source note | uspto-grants-1983_04 |
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