Hydrochloric Acid → HCID 13252412, compound

Participants

Reaction Steps

In 220 ml of ethanol was suspended 25.0 g of 2-(4-chloro-2-fluorophenyl)-3a-hydroxy-3-imino-octahydroisoindol-1-thione and 20 ml of concentrated hydrochloric acid was added to the suspension, followed by stirring at 50° to 60° C. for several minutes. After cooling, 200 ml of water was added to the mixture, and the resulting crystals were collected by filtration, washed with 50% ethanol and dried, thereby producing 20.8 g (yield of 83%) of the subject compound. Recrystallization from ethanol yielded slightly yellow crystals, m.p. 156°-157° C.

Provenance & Evidence