2-Fluoro-5-nitrobenzoic acid → 5-Amino-2-fluorobenzoic acid

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Reaction Steps

One hundred eleven g of 2-fluoro-5-nitrobenzoic acid was dissloved in 1 liter of ethyl acetate. To this solution was added 5 g of 5 percent palladium on charcoal. The mixture was hydrogenated on a Parr apparatus for 24 hours at 20° C. at 50 psi of hydrogen. The theoretical amount of hydrogen was absorbed. The solution was filtered, then evaporated to dryness to provide a tan residue of 95.2 g of 5-amino-2-fluorobenzoic acid.

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