2,6-Difluorobenzoyl isocyanate → HCID 15582694, compound

HRID 1702182Notes

Reaction equation

HRID 1702182 reaction equation
[CH2:1]([C:3]1[O:4][C:5]([NH2:13])=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1)[CH3:2].[F:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:16]=1[C:17]([N:19]=[C:20]=[O:21])=[O:18]>C(#N)C>[F:14][C:15]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[C:16]=1[C:17]([NH:19][C:20]([NH:13][C:5]1[O:4][C:3]([CH2:1][CH3:2])=[N:7][C:6]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:21])=[O:18]

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 15582693Ethyl 5-amino-2-ethyl-1,3-oxazole-4-carboxylate

Product 1

HCID 15582694HCID 15582694, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
25 °C

Procedure

To 0.5 g. 2-ethyl-4-carbethoxy-5-aminooxazole dissolved in 20 ml. acetonitrile was added 0.7 g. 2,6-difluorobenzoylisocyanate under nitrogen at about 25° C. The reaction mixture was stirred at about 25° C. for 3 hours and the solid was collected. Yield 0.36 g.

Workup

  1. customat about 25° C
  2. customthe solid was collected

Sources & evidence

ORD record
ord-bdffbaed7a1e433b9480837b07acee59
Source dataset
uspto-grants-1983_04
Patent number
US04380641

Reaction notes

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