ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE → HCID 15582695, compound

HRID 1702183Notes

Reaction equation

HRID 1702183 reaction equation
[CH3:1][C:2]1[O:3][C:4]([NH2:12])=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.[Cl:13][C:14]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:15]=1[C:16]([N:18]=[C:19]=[O:20])=[O:17]>C(#N)C>[Cl:13][C:14]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:15]=1[C:16]([NH:18][C:19]([NH:12][C:4]1[O:3][C:2]([CH3:1])=[N:6][C:5]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:20])=[O:17]

Participants

4

Reactant 2

HCID 414072ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATEHCID 130517312-Chloro-6-fluorobenzoyl isocyanate

Product 1

HCID 15582695HCID 15582695, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
25 °C

Procedure

To 0.6 g. 2-methyl-4-carbethoxy-5-aminooxazole dissolved in 25 ml. acetonitrile was added 0.8 2-chloro-6-fluorobenzoylisocyanate under nitrogen at about 25° C. The reaction mixture was stirred at 25° C. for 12 hours and the solid was collected. Yield 0.7 g.

Workup

  1. customthe solid was collected

Sources & evidence

ORD record
ord-1cee31a8ecc14bb0ab5c3daf71f2e7c8
Source dataset
uspto-grants-1983_04
Patent number
US04380641

Reaction notes

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