HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → HCID 178482511, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | (3-Mercaptopropyl)ammonium chloride | HCID 197870 | — |
| Reactant | (2-((Dimethylamino)methyl)thiazol-4-yl)methanol | HCID 1838020 | — |
| Reactant | 3,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxide | HCID 12230538 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 178482511 | HCID 178482511 | — |
Reaction Steps
When 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Example 34, Step D] is reacted with 3-mercaptopropylamine hydrochloride [prepared according to the procedure described in J. Org. Chem., 27, 2846 (1962)] in aqueous hydrobromic acid (48%), and the resultant amine is successively treated with 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide and excess methylamine as in the general procedure of Example 31, the title compound is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04380638 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-c918fdbfba03496dbcb7c8e07cbb5a2f |
| Source note | uspto-grants-1983_04 |