3,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxide → HCID 178434785, compound

HRID 1702292Notes

Reaction equation

HRID 1702292 reaction equation
COC1C(OC)=NS(=O)(=O)N=1.CN(CC1SC(CSCCN)=CC=1)C.[CH3:26][N:27]([CH2:29][C:30]1[S:34][C:33]([CH2:35][S:36][CH2:37][CH2:38][NH:39][C:40]2[C:44](OC)=[N:43][S:42](=[O:48])(=[O:47])[N:41]=2)=[CH:32][CH:31]=1)[CH3:28].[CH3:49][C:50]1[C:51]([CH2:55][S:56][CH2:57][CH2:58][NH2:59])=[N:52][O:53][N:54]=1>>[CH3:26][N:27]([CH2:29][C:30]1[S:34][C:33]([CH2:35][S:36][CH2:37][CH2:38][NH:39][C:40]2[C:44]([NH:59][CH2:58][CH2:57][S:56][CH2:55][C:51]3[C:50]([CH3:49])=[N:54][O:53][N:52]=3)=[N:43][S:42](=[O:48])(=[O:47])[N:41]=2)=[CH:32][CH:31]=1)[CH3:28]

Participants

5

Reactant 4

HCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxideHCID 129139512-(5-Dimethylaminomethyl-2-thienylmethylthio)ethylamineHCID 131028982-[(4-Methyl-1,2,5-oxadiazol-3-yl)methylthio]ethylamineHCID 178494330HCID 178494330, compound

Product 1

HCID 178434785HCID 178434785, compound

Procedure

When a suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide is reacted with an equimolar amount of 2-[(5-dimethylaminomethyl-2-thienyl)methylthio]ethylamine and the resultant 3-{2-[(5-dimethylaminomethyl-2-thienyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide is treated with 2-[(4-methyl-1,2,5-oxadiazol-3-yl)methylthio]ethylamine [prepared in Example 58, Step B], the title compound is thereby produced.

Sources & evidence

ORD record
ord-ada6c308e64a48e8bffa94d5983ef995
Source dataset
uspto-grants-1983_04
Patent number
US04380638

Reaction notes

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